The small leucine-rich proteoglycans (SLRPs), decorin and biglycan, are key regulators of collagen fibril and matrix assembly. The goal of this work was to elucidate the roles of decorin and biglycan in tendon homeostasis. Our central hypothesis is that decorin and biglycan expression in the mature tendon would be critical for the maintenance of the structural and mechanical properties of healthy tendons.
Spontaneous rupture of the Achilles tendon is increasingly common in the middle aged population. However, the cause for the particularly high incidence of injury in this age group is not well understood. Therefore, the objective of this study was to identify age-specific differences in the Achilles tendon-muscle complex using an animal model.
The objective of this study was to identify acute responses and chronic adaptations of supraspinatus tendon to non-injurious exercise. We hypothesized that chronic exercise increases tendon mechanical properties, and a single exercise bout increases MMP activity acutely. Rats were divided into acute or chronic exercise (EX) or cage activity (CA) groups.