Estrogen receptor alpha mediates mandibular condylar cartilage growth in male mice

In the appendicular skeleton, estrogen via ERα signalling has been shown to mediate endochondral growth plate fusion in both males and females. However, the role of ERα in mediating growth of the mandibular condylar cartilage is unknown. Thus, this study focuses on the characterization of the mandibular condylar cartilage phenotype in young and adult male ERαKO mice.

Whole grape alleviates inflammatory arthritis through inhibition of tumor necrosis factor

The anti-rheumatic efficacy of grape powder (GP) diet was evaluated in transgenic mice (TG) overexpressing human tumor necrosis factor (TNF), a model for rheumatoid arthritis (RA). After 4-weeks, TG mice fed on 10% of GP showed improvement with epiphyseal bone mass (p = 0.07) compared to TG fed on a regular diet. TG mice that received 5 or 10% of GP exhibited a significant (p < 0.05) decrease in resorption-associated osteoclasts in paw and knee joints.

EGFR signaling is critical for maintaining the superficial layer of articular cartilage and preventing osteoarthritis initiation

Osteoarthritis (OA) is the most common joint disease, characterized by progressive destruction of the articular cartilage. The surface of joint cartilage is the first defensive and affected site of OA, but our knowledge of genesis and homeostasis of this superficial zone is scarce. EGFR signaling is important for tissue homeostasis.

Treatment of Articular Cartilage Defects With Microfracture and Autologous Matrix-Induced Chondrogenesis Leads to Extensive Subchondral Bone Cyst Formation in a Sheep Model

Microfracture and the autologous matrix-induced chondrogenesis (AMIC) technique are popular for the treatment of articular cartilage defects. However, breaching of the subchondral bone plate could compromise the subchondral bone structure.

Increased mandibular condylar growth in mice with estrogen receptor beta deficiency

Temporomandibular joint (TMJ) disorders predominantly afflict women of childbearing age, suggesting a role for female hormones in the disease process. In long bones, estrogen acting via estrogen receptor beta (ERβ) inhibits axial skeletal growth in female mice.

A Comparative Analysis of the Articular Cartilage in the Temporomandibular Joint of Gouging and Nongouging New World Monkeys

Both laboratory and field data demonstrate that marmosets gouge trees with wide jaw gapes to elicit exudate flow. Tree gouging distinguishes marmosets from other platyrrhines and presents a natural experiment for studying the morphological consequences of this derived feeding behavior. We utilize comparative histomorphometrics to determine whether loading of the TMJ at wide jaw gapes impacts articular cartilage form in two habitual gouging species