Effects of NSAIDs and hydroxyapatite coating on osseointegration Biomechanical and histological study on rabbits


Ahmet Salduz, Fatih Dikici, Önder Ismet Kılıçoğlu, Halil Ibrahim Balcı, Turgut Akgul, Mehmet Kürkçü, Cem Kurtoğlu, Remzi Tözün


The aim of our study is to investigate the bone ongrowth of two different alternative surfaces and the effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on osseointegration.

Hips of 40 New Zealand white rabbits were operated bilaterally. Hydroxyapatite (HA)-coated titanium rods were implanted into the right femur, and grit-blasted titanium rods were implanted into the left femur. They were divided into three groups. At the end of 8 weeks, both femora of the rabbits were removed and investigated biomechanically and histologically.

HA-coated implants had a significantly better failure load and “percentage of bone–implant contact” than grit-blasted implants. There was no significant difference between the medication groups as a result of the biomechanical and histologic investigations.

Our results indicate that NSAIDs did not have any negative effect on the osseointegration. HA-coated implants may provide more tensile strength and greater bone–implant contact rate in comparison with grit-blasted implants.