An Liu, Miao Sun, Huifeng Shao, Xianyan Yang, Chiyuan Ma, Dongshuang He, Qing Gao, Yanming Liu, Shigui Yan, Sanzhong Xu, Yong HE, JianZhong Fu and Zhongru Gou
The regeneration and repair of damaged load-bearing segmental bone requires considerable mechanical strength for the artificial implants. The ideal biomaterials should also facilitate the production of porous implants with high bioactivity desirable for stimulating new bone growth. Here we developed a new mechanically strong, highly bioactive, dilute magnesium-doped wollastonite (CaSiO3-Mg; CSi-Mg) porous scaffold by the robocasting technique. The sintered scaffolds had interconnected pores of 350 μm in size and over 50% porosity with appreciable compressive strength (>110 MPa), 5−10 times higher than those of pure CSi and β-TCP porous ceramics. Extensive in vitro and in vivo investigations revealed that such Ca-silicate bioceramic scaffolds were particularly beneficial for osteogenic cell activity and osteogenic capacity in critical size femoral bone defects. The CSi-Mg porous constructs were accompanied by an accelerated new bone growth (6‒18 weeks) and a mechanically outstanding elastoplastic response to finally match the strength (10−15 MPa) of the rabbit femur host bone after 18 weeks, and the material itself experienced mild resorption and apatite-like phase transformation. In contrast, the new bone regeneration in the β-TCP scaffolds was substantially retarded after 6‒12 weeks implantation, and exhibited a low level of mechanical strength (<10 MPa) similar to the pure CSi scaffolds. These results suggest a promising application of robocast CSi-Mg scaffolds in clinic, especially for the load-bearing bone defects.
Link to Article